Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an underground arms cache in Syria operated by the IS group, according to the UK's MoD.
The site, located using intelligence, was assessed as storing arms and explosives, the release indicated, and was situated in mountainous terrain just above the ancient city of Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to hit a several entry passages down to the site... preliminary assessments are that the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the strike conducted Saturday night and each participating jet returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - also known as the so-called Islamic State - imposed extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation underscores the UK's leading role, and resolve to work closely with our partners, to stamp out any resurgence of Daesh and their violent and radical beliefs in the area," UK Defence Secretary John Healey stated.
RAF aircraft have carried out overwatch operations over Syrian airspace to "deter any attempted comeback" of IS following its routing at the battle of Baghuz in 2019, the ministry said.
"I must thank the personnel of our armed forces involved in this strike for their expertise and their bravery," the Defence Secretary added. "Including them were numerous UK service members on duty over Christmas and New Year. This mission, to eliminate dangerous terrorists who threaten our way of life, shows how British military are always on standby, continuously, ensuring Britain's security at home and powerful internationally."
During December, the United States armed forces carried out what it described as a "large-scale strike" targeting IS targets in Syria, following an attack claimed the lives of two US troops and a local interpreter in Palmyra.
The U.N. reports Islamic State still boasts between 5,000 and 7,000 militants in Iraq and Syria.
